Drosophila models of neurodegenerative disease
نویسندگان
چکیده
منابع مشابه
Drosophila in the Study of Neurodegenerative Disease
As populations benefit from increasing lifespans, neurodegenerative diseases have emerged as a critical health concern. How can the fruit fly, Drosophila melanogaster, contribute to curing human diseases of the nervous system? A growing number of neurodegenerative diseases, as well as other human diseases, are being modeled in Drosophila and used as a platform to identify and validate cellular ...
متن کاملGuide to Understanding Drosophila Models of Neurodegenerative Diseases
Primer I n the decade since human genes associated with neurodegenerative disease were first used in flies to create pathological phenotypes [1–5], a minor industry has sprung up using flies as a model to study the mechanisms underlying central nervous system malfunction in humans. Why study neurodegeneration in flies? Their small size, rapid generation time, and low costs for maintenance as co...
متن کاملEvaluation of Traditional Medicines for Neurodegenerative Diseases Using Drosophila Models
Drosophila is one of the oldest and most powerful genetic models and has led to novel insights into a variety of biological processes. Recently, Drosophila has emerged as a model system to study human diseases, including several important neurodegenerative diseases. Because of the genomic similarity between Drosophila and humans, Drosophila neurodegenerative disease models exhibit a variety of ...
متن کاملFrom fruit fly to bedside: translating lessons from Drosophila models of neurodegenerative disease.
PURPOSE OF REVIEW Fly models have been developed for a variety of neurodegenerative disorders, and the field is beginning to harness the power of Drosophila genetics to dissect pathways of disease pathogenesis and identify targets for therapeutic intervention. In this review, we emphasize the most recent accomplishments and chart the potential rewards in translating lessons from Drosophila mode...
متن کاملUncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease
Common neurodegenerative proteinopathies, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the misfolding and aggregation of toxic protein species, including the amyloid beta (Aß) peptide, microtubule-associated protein Tau (Tau), and alpha-synuclein (αSyn) protein. These factors also show toxicity in Drosophila; however, potential limitations of prior studies...
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ژورنال
عنوان ژورنال: NeuroRX
سال: 2005
ISSN: 1545-5343
DOI: 10.1602/neurorx.2.3.438